National Chromatography Inco
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Ultimasyil Diol 150A HPLC Columns are designed for advanced polar compound separation using a diol (–CH₂CH(OH)CH₂OH) bonded phase on high-purity silica with a 150 Å pore size. This wider pore size enhances the separation of larger molecules such as peptides, oligosaccharides, and small proteins, making these columns ideal for both normal-phase and HILIC (Hydrophilic Interaction Liquid Chromatography) applications.
Advantages:
Selective Retention of Polar Analytes: Excellent for carbohydrates, hydrophilic drugs, and sugar derivatives
Wider Pore Size: Facilitates access for larger molecules like peptides and glycans
Dual-Mode Flexibility: Works in both aqueous-organic HILIC and traditional normal-phase conditions
Low Bleed & High Stability: LC-MS compatible and robust under standard pH range
Improved Peak Symmetry: Reduced tailing for better quantification and reproducibility
Common Applications:
Peptide and glycan mapping
Carbohydrate and sugar alcohol analysis
Hydrophilic drug compound profiling
Bioactive natural products
HILIC-MS workflows for metabolomics and proteomics
