National Chromatography Inco
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Hi-Purit™ Cyano 40–63 µm Flash Cartridges are specialized chromatography products designed for flash column chromatography, a common technique used in organic chemistry for purification of compounds.
Key Features:
Stationary phase: Silica gel functionalized with cyano (–CN) groups.
Particle size: 40–63 micrometers — standard for flash chromatography.
Pre-packed cartridge: Ready-to-use format for fast, reproducible separations.
Typical Uses of Hi-Purit™ Cyano Flash Cartridges:
Purification of Organic Compounds:
Ideal for intermediate polarity compounds.
Cyano-modified silica has different selectivity compared to regular silica — especially useful when normal-phase silica doesn't give clean separation.
Separation of Isomers or Closely Related Structures:
The polar cyano group interacts via dipole-dipole interactions and can separate compounds with subtle structural differences.
Polarity-Tailored Separations:
Offers an intermediate polarity between silica and reversed-phase C18 columns.
Useful when compounds are too polar for C18 but not retained enough on pure silica.
Purification in Drug Discovery or Natural Products Chemistry:
Frequently used in medicinal chemistry labs to purify small molecule leads.
Effective for separating basic, neutral, and some acidic compounds.
Analytical Method Development:
Helps develop separation strategies for scale-up or HPLC methods by understanding compound behavior on cyano phases.
